Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs
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چکیده
منابع مشابه
BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues.
Several psychiatric disorders have been associated with CpG methylation changes in CG rich promoters of the brain-derived neurotrophic factor (BDNF) mainly by extracting DNA from peripheral blood cells. Whether changes in peripheral DNA methylation can be used as a proxy for brain-specific alterations remains an open question. In this study we aimed to compare DNA methylation levels in BDNF pro...
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Chronic alcoholism is a multi-factorial psychiatric disease manifested by re-occurring periods of relapse with frequent symptoms of cognitive impairments. There is no explanation to the extreme vulnerability to relapse, since this often occurs without evident molecular or biochemical changes remaining at the time of relapse. Epigenetic marks, such as DNA methylation, may represent a memory of m...
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Although most CpG islands are generally thought to remain unmethylated in all adult somatic tissues, recent genome-wide approaches have found that some CpG islands have distinct methylation patterns in various tissues, with most differences being seen between germ cells and somatic tissues. Few studies have addressed this among human somatic tissues and fewer still have studied the same sets of...
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The brain tissue obtained after death is subjected to several circumstances that can affect RNA integrity. The present study has been directed to reveal possible pitfalls and to control RNA normalization in post-mortem samples in order to recognize the limitations and minimize errors when using TaqMan PCR technology. This has been carried out in samples of the frontal cortex in a series of cont...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2011
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32833eecbc